Type 1 interferon contributes to CD 4 + T cell depletion 1 in HIV - 1 induced human thymus
نویسندگان
چکیده
1 Department of Microbiology and Immunology, 2 the Lineberger Comprehensive Cancer 9 Center, School of Medicine, The University of North Carolina, Chapel Hill, NC 2759910 729, 3 Key Lab for Infection and Immunity and National Laboratory of 11 Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Da Tun 12 Road, Chaoyang District, Beijing 100101, China 13 14 *Corresponding author: Lishan Su, Lineberger Comprehensive Cancer Center, CB#7295, 15 Chapel Hill, NC 27599, [email protected], 16 Phone 919 966-6654, Fax 919 966-8212 17 18 Abstract words: 100 19 Text words: 1,115 20 Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.00457-11 JVI Accepts, published online ahead of print on 22 June 2011
منابع مشابه
Type I interferon contributes to CD4+ T cell depletion induced by infection with HIV-1 in the human thymus.
Persistent induction of type 1 interferon (IFN) is associated with human immunodeficiency virus type 1 (HIV-1) infection. We report here that the pathogenic HIV strain R3A (HIV-R3A) induced high levels of type 1 IFN, while the nonpathogenic HIV-R3B showed no significant induction in human fetal thymus organ culture (HFTOC). We found that IFN contributed to the depletion of human T cells by HIV-...
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تاریخ انتشار 2011